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Journal of Antimicrobial Chemotherapy 2009 63(Supplement 1):i14-i15; doi:10.1093/jac/dkp075
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© The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

This article appears in the following Journal of Antimicrobial Chemotherapy issue: The changing face of febrile neutropenia-from monotherapy to moulds to mucositis [View the issue table of contents]

Articles

Why empirical therapy?

Jean Klastersky*

Department of Medicine, Institut Jules Bordet, 1000 Brussels, Belgium

* Tel: +32-254-13201; Fax: +32-054-13202; E-mail: jean.klastersky{at}bordet.be

Why empirical therapy? Because it works! Empirical antimicrobial therapy is a reasonable, pragmatic approach to limit the ominous threat of Gram-negative sepsis in febrile neutropenic cancer patients. Empirical treatment of occult fungal infection in patients with neutropenia and persistent fever, in spite of initial broad-spectrum antimicrobial coverage, is effective but the role of pre-emptive treatment remains to be established.

Keywords: neutropenic fever , infection in cancer , prophylaxis


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