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JAC Advance Access originally published online on December 2, 2008
Journal of Antimicrobial Chemotherapy 2009 63(2):361-364; doi:10.1093/jac/dkn497
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Posaconazole efficacy in a murine disseminated infection caused by Paecilomyces lilacinus

M. Mar Rodríguez, F. Javier Pastor, Carolina Serena and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 18 August 2008; returned 6 October 2008; revised 11 November 2008; accepted 12 November 2008

* Corresponding author. Tel: +34 977-759359; Fax: +34 977-759322; E-mail: josep.guarro{at}urv.cat

Objectives: We have compared the efficacy of posaconazole and amphotericin B in an experimental murine model of paecilomycosis.

Methods: Immunosuppressed mice were treated with posaconazole at 25, 50, 75 or 100 mg/kg/day orally, amphotericin B at 1.5 or 3 mg/kg/day intraperitoneally or liposomal amphotericin B at 5 mg/kg/day intravenously. Treatment began 1 day after infection and continued for 10 days post-infection. Two strains of Paecilomyces lilacinus were tested.

Results: Posaconazole at 50 mg/kg/day was the only treatment able to significantly reduce fungal loads in the spleens, kidneys and livers of the mice infected by each of the two strains.

Conclusions: The results suggest that posaconazole may have a clinical role in the treatment of disseminated paecilomycosis.

Keywords: amphotericin B , murine model , paecilomycosis


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