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JAC Advance Access originally published online on February 8, 2008
Journal of Antimicrobial Chemotherapy 2008 61(4):831-834; doi:10.1093/jac/dkn040
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli

Kieran A. Ryan1,2, Paul Daly1,2, Yin Li1,2, Carmel Hooton3 and Paul W. O'Toole1,2,*

1 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; 2 Department of Microbiology, University College Cork, Cork, Ireland; 3 Department of Microbiology, Cork University Hospital, Cork, Ireland

Received 3 December 2007; returned 9 January 2008; revised 11 January 2008; accepted 15 January 2008

* Corresponding author. Tel: +353-21-490-3997; Fax: +353-21-490-3101; E-mail: pwotoole{at}ucc.ie

Objectives: To investigate the anti-Helicobacter pylori activity of 28 strains of Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites and from different geographical regions.

Methods: An in vitro agar plate diffusion assay was employed to assess the Lactobacillus anti-H. pylori activity.

Results: Nine out of 28 L. salivarius strains and 3/12 other Lactobacillus species tested inhibited H. pylori growth. There was no correlation between ecological niche/geographical location of isolation of the lactobacilli and their inhibitory capability. Further studies on strain L. salivarius UCC119 showed that this strain could inhibit growth of 6/6 clinical isolates of H. pylori, five of which were antibiotic-resistant. This inhibition was not due to acid production and was not mediated by a protein, but did require the presence of live cells.

Conclusions: Growth inhibition of H. pylori by L. salivarius is strain-dependent and is not linked to any particular environmental niche or geographic location. Strains of L. salivarius showing highest anti-H. pylori activity may be useful as an adjunct in the treatment of strains that are resistant to conventional antibiotics.

Keywords: probiotics , antibiotic resistance , bacteriocins


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