Skip Navigation


JAC Advance Access originally published online on February 8, 2008
Journal of Antimicrobial Chemotherapy 2008 61(4):805-809; doi:10.1093/jac/dkn022
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
61/4/805    most recent
dkn022v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Alastruey-Izquierdo, A.
Right arrow Articles by Rodríguez-Tudela, J. L.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alastruey-Izquierdo, A.
Right arrow Articles by Rodríguez-Tudela, J. L.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Original research

Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods

Ana Alastruey-Izquierdo, Manuel Cuenca-Estrella, Araceli Monzón, Emilia Mellado and Juan Luís Rodríguez-Tudela*

Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain

Received 20 July 2007; returned 30 October 2007; revised 3 December 2007; accepted 3 January 2008


* Corresponding author. Tel: +34-918223919; Fax: +34-915097966; E-mail: jlrtudela{at}isciii.es

Objectives: To analyse the susceptibility pattern of a collection of Fusarium clinical isolates.

Methods: The antifungal susceptibility pattern of 67 isolates of Fusarium was analysed. Strains were identified by morphological and molecular methods by means of sequencing elongation factor {alpha}.

Results and conclusions: Six different species were identified. Fusarium solani was the most frequently isolated, followed by Fusarium oxysporum, Fusarium proliferatum and Fusarium verticilloides. Amphotericin B was the only drug with in vitro activity (range: 0.015–32 mg/L). The rest of the antifungals tested (itraconazole, voriconazole, ravuconazole, posaconazole and terbinafine) showed very poor activity against Fusarium, confirming the multiresistant nature of this genus.

Keywords: elongation factor {alpha} , antifungal resistance , emerging moulds


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.