JAC Advance Access originally published online on August 29, 2007
Journal of Antimicrobial Chemotherapy 2007 60(5):1163-1167; doi:10.1093/jac/dkm305
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High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea
1 Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea 2 Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Seoul, Korea 3 Division of Infectious Diseases, Daegu Fatima Hospital, Daegu, Korea 4 Division of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea 5 Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Received 25 April 2007; returned 21 June 2007; revised 9 July 2007; accepted 19 July 2007
* Correspondence address. Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University, and Asian-Pacific Research Foundation for Infectious Diseases (ARFID), 50 Il-won dong, Gangnam-gu, Seoul 135-710, Korea. Tel: +82-2-3410-0320; Fax: +82-2-3410-0328; E-mail: jhsong{at}smc.samsung.co.kr
Objectives: To investigate antimicrobial resistance in clinical isolates of Acinetobacter spp. from two Korean hospitals.
Methods: Two hundred and sixty-five isolates of Acinetobacter spp. from two Korean hospitals were collected and were identified to species level using partial rpoB gene sequences. Antimicrobial susceptibility testing was performed using a broth microdilution method.
Results: rpoB gene sequences indicated that 214 isolates (80.8%) were Acinetobacter baumannii, and allowed these to be classified into three subgroups (I, II and III); 142 isolates (53.6%) belonged to subgroup I, 54 (20.4%) to subgroup II and 18 (6.8%) to subgroup III. Forty-eight isolates (18.1%) and 74 isolates (27.9%) were resistant to polymyxin B and colistin, respectively. However, antimicrobial resistance rates varied markedly between subgroups. While A. baumannii subgroup I showed low resistance rates to polymyxin B and colistin (2.1% and 7.0%, respectively), subgroups II and III showed high resistance rates to these antibiotics (38.9% and 64.8% in subgroup II and 72.2% and 88.9%, in subgroup III, respectively). Multidrug resistance was also significantly more frequent in subgroup I (45.1%) than in subgroups II and III (13.0% and 16.7%, respectively).
Conclusions: Our data indicate that subgroup identification of A. baumannii may aid selection of appropriate antimicrobial agents for the treatment of Acinetobacter infections.
Keywords: rpoB , antimicrobial resistance , subgrouping
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