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JAC Advance Access originally published online on September 17, 2007
Journal of Antimicrobial Chemotherapy 2007 60(5):1004-1009; doi:10.1093/jac/dkm350
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Correlation of posaconazole minimum fungicidal concentration and time–kill test against nine Candida species

G. Sóczó1, G. Kardos1, P. M. McNicholas2, E. Balogh1, L. Gergely1, I. Varga3, B. Kelentey3 and L. Majoros1,*

1 Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Hungary 2 Schering-Plough Research Institute, Kenilworth, NJ, USA 3 Faculty of Dentistry, Medical and Health Science Center, University of Debrecen, Hungary

Received 13 March 2007; returned 21 May 2007; revised 30 July 2007; accepted 15 August 2007

* Corresponding author. Tel: +36-52-411-717/4501; Fax: +36-52-414-948; E-mail: major{at}dote.hu

Objectives: We evaluated the in vitro activity of posaconazole against nine Candida species using minimum fungicidal concentration (MFC) measurements and time–kill methods.

Methods: MFCs of posaconazole were determined for 209 clinical isolates (32 Candida albicans, 30 Candida glabrata, 21 Candida tropicalis, 29 Candida krusei, 28 Candida parapsilosis sensu stricto, 50 Candida inconspicua, 13 Candida kefyr, 3 Candida lusitaniae and 3 Candida guilliermondii) and 7 ATCC Candida strains. The following strains were tested in time–kill studies: 3 strains each of C. glabrata, C. kefyr, C. guilliermondii and C. lusitaniae; 2 C. tropicalis; 4 C. albicans; 4 C. inconspicua; 9 C. krusei; 12 C. parapsilosis; and 7 ATCC strains.

Results: Posaconazole was fungicidal in both MFC and time–kill experiments (at 2 mg/L within 48 h in time–kill assays) against each C. krusei, C. inconspicua and C. lusitaniae strain and was fungistatic against each C. albicans, C. glabrata, C. tropicalis and C. guilliermondii strain. For the C. parapsilosis strains, posaconazole MFCs were ≤2 mg/L for 20 of the 28 isolates tested; however, in the time–kill tests, even at drug concentrations of 32–64 x MIC, posaconazole was fungistatic against all C. parapsilosis strains tested.

Conclusions: MFC values were good predictors of the fungistatic or fungicidal activity of posaconazole, as determined by time–kill curves, for all tested species except C. parapsilosis. Our results highlight the fungicidal action of posaconazole against a number of clinically relevant Candida species.

Keywords: MFCs , antifungals , triazoles


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