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JAC Advance Access originally published online on July 23, 2007
Journal of Antimicrobial Chemotherapy 2007 60(3):459-460; doi:10.1093/jac/dkm260
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leading articles

Invasive Candida species infection: the importance of adequate empirical antifungal therapy

Darius Armstrong-James*

Department of Molecular Microbiology and Infection, Flowers Building, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

* Tel: +44-207-589-5111; E-mail: d.armstrong{at}imperial.ac.uk

Candida species are a common cause of bloodstream and invasive infection in critically ill and immunosuppressed patients. Furthermore, invasive Candida infection carries a poor prognosis and may initially be mistaken for bacterial infection. An article in this issue of the Journal investigates the relationship between adequacy of initial empirical therapy and outcome from invasive Candida infection. This study shows that adequate empirical therapy is received by only a quarter of patients, and that inappropriate therapy is associated with increased mortality. These findings highlight the importance of appropriate empirical therapy in invasive Candida infection.

Keywords: antifungal therapy , candidiasis , clinical mycology


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