JAC Advance Access originally published online on May 11, 2007
Journal of Antimicrobial Chemotherapy 2007 60(1):140-144; doi:10.1093/jac/dkm144
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Community emergence of CTX-M type extended-spectrum ß-lactamases among urinary Escherichia coli from women
1 Division of Infectious Diseases, Department of Microbiology and Centre of Infection, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, China 2 The Laboratory, St Teresa's Hospital, Prince Edward Road, Hong Kong Special Administrative Region, China 3 Pathlab Medical Laboratories Ltd, Jaffe Road, Hong Kong Special Administrative Region, China 4 Department of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, China
Received 21 January 2007; returned 31 January 2007; revised 16 April 2007; accepted 16 April 2007
* Corresponding author. Tel: +852-2855-4897; Fax: +852-2855-1241; E-mail: plho{at}hkucc.hku.hk
Objectives: To conduct a territory-wide study of extended-spectrum ß-lactamases (ESBLs) among community isolates of urinary Escherichia coli from women in Hong Kong.
Methods: Up to 50 consecutive single-patient E. coli isolates, collected from 13 laboratories in 2004, were studied. The ESBLs were characterized by PCR sequencing using specific primers. The epidemiological relationship of the isolates was studied by PFGE and phylogenetic group PCRs.
Results: Forty-two ESBL producers were found among 600 consecutive isolates tested. The ESBL prevalence was 7.3% (15/205) for women aged 18–35 years, 5% (11/219) for women aged 36–50 years, 6.3% (4/63) for women aged 51–64 years and 10.6% (12/113) for women aged 
65 years (P = 0.3). The ESBL-producing isolates were often multidrug-resistant and CTX-M-14 was found in 37 isolates, CTX-M-15 in 3 isolates and CTX-M-3 in 2 isolates. PFGE revealed no significant clusters among the ESBL producers. Overall, CTX-M-14 producers were significantly more likely to belong to group D than non-ESBL producers [18/37 (48.6%) versus 13/57 (22.8%), P = 0.009]. However, 7 of 13 (53.8%) CTX-M-14 producers from women aged 18–35 years represented phylogenetic group B2, compared with 7 of 24 (29.2%) for women of all other ages (P = 0.1).
Conclusions: The study documented the community emergence of CTX-M as the predominant ESBL type among urinary isolates from women. The spread of CTX-M enzymes among isolates from young women is concerning and deserves close monitoring.
Keywords: antimicrobial resistance epidemiology , urinary tract infections , fluoroquinolones , pulsed-field gel electrophoresis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Valverde, R. Canton, M. P. Garcillan-Barcia, A. Novais, J. C. Galan, A. Alvarado, F. de la Cruz, F. Baquero, and T. M. Coque Spread of blaCTX-M-14 Is Driven Mainly by IncK Plasmids Disseminated among Escherichia coli Phylogroups A, B1, and D in Spain Antimicrob. Agents Chemother., December 1, 2009; 53(12): 5204 - 5212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Woodford, A. Carattoli, E. Karisik, A. Underwood, M. J. Ellington, and D. M. Livermore Complete Nucleotide Sequences of Plasmids pEK204, pEK499, and pEK516, Encoding CTX-M Enzymes in Three Major Escherichia coli Lineages from the United Kingdom, All Belonging to the International O25:H4-ST131 Clone Antimicrob. Agents Chemother., October 1, 2009; 53(10): 4472 - 4482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liu, L. Chen, H. Li, H. Duan, Y. Zhang, X. Liang, X. Li, M. Zou, L. Xu, and P. M. Hawkey Novel CTX-M {beta}-lactamase genotype distribution and spread into multiple species of Enterobacteriaceae in Changsha, Southern China J. Antimicrob. Chemother., May 1, 2009; 63(5): 895 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Prakash, J. S. Lewis II, M. L. Herrera, B. L. Wickes, and J. H. Jorgensen Oral and Parenteral Therapeutic Options for Outpatient Urinary Infections Caused by Enterobacteriaceae Producing CTX-M Extended-Spectrum {beta}-Lactamases Antimicrob. Agents Chemother., March 1, 2009; 53(3): 1278 - 1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cui, J. Li, Z. Sun, C. Hu, S. Jin, F. Li, Y. Guo, L. Ran, and Y. Ma Characterization of Salmonella enterica isolates from infants and toddlers in Wuhan, China J. Antimicrob. Chemother., January 1, 2009; 63(1): 87 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yumuk, G. Afacan, M.-H. Nicolas-Chanoine, A. Sotto, and J.-P. Lavigne Turkey: a further country concerned by community-acquired Escherichia coli clone O25-ST131 producing CTX-M-15 J. Antimicrob. Chemother., August 1, 2008; 62(2): 284 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vinue, M. Lantero, Y. Saenz, S. Somalo, I. de Diego, F. Perez, F. Ruiz-Larrea, M. Zarazaga, and C. Torres Characterization of extended-spectrum {beta}-lactamases and integrons in Escherichia coli isolates in a Spanish hospital J. Med. Microbiol., July 1, 2008; 57(7): 916 - 920. [Full Text] [PDF]
|
|