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JAC Advance Access originally published online on March 5, 2007
Journal of Antimicrobial Chemotherapy 2007 59(4):633-639; doi:10.1093/jac/dkm007
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Differences in phenotypic and genotypic traits against antimicrobial agents between Acinetobacter baumannii and Acinetobacter genomic species 13TU

Jung Hoon Lee1, Chul Hee Choi1, Hee Young Kang1, Ji Young Lee1, Jungmin Kim1, Yoo Chul Lee1, Sung Yong Seol1, Dong Taek Cho1, Kun Woo Kim2, Do Young Song3 and Je Chul Lee1,*

1 Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea 2 Department of Internal Medicine, Daegu Fatima Hospital, Daegu 701-600, Republic of Korea 3 Department of Clinical Pathology, Daegu Fatima Hospital, Daegu 701-600, Republic of Korea

Received 19 October 2006; returned 15 December 2006; revised 11 January 2007; accepted 12 January 2007

* Corresponding author. Tel: +82-53-420-4844; Fax: +82-53-427-5664; E-mail: leejc{at}knu.ac.kr

Objectives: To investigate the differences in antimicrobial susceptibility and resistance mechanisms against imipenem between Acinetobacter baumannii and Acinetobacter genomic species 13TU.

Methods: A total of 232 non-duplicate Acinetobacter species were consecutively collected from two Korean hospitals in Daegu, Republic of Korea, between November 2004 and November 2005. Antimicrobial susceptibility was determined by agar dilution methods. Resistance to imipenem was characterized by a carbapenemase activity test and PCR amplification. PFGE was performed to determine the clonal relatedness of imipenem-resistant Acinetobacter species.

Results: A. baumannii was the most prevalent species (61.2%), followed by Acinetobacter genomic species 13TU (25.9%). The resistance rates of A. baumannii to most antimicrobial agents were higher than those of other Acinetobacter species, while the resistance rate to imipenem was the highest in Acinetobacter genomic species 13TU. Imipenem-resistant Acinetobacter genomic species 13TU isolates produced VIM-2 metallo-ß-lactamase, while imipenem-resistant A. baumannii isolates produced OXA-23 and/or OXA-51 ß-lactamase. Imipenem-resistant Acinetobacter strains originated from different clones in each hospital.

Conclusions: Two prevalent Acinetobacter species, A. baumannii and Acinetobacter genomic species 13TU, possess distinct phenotypic and genotypic traits against antimicrobials.

Keywords: carbapenem resistance , metallo-ß-lactamases , ß-lactamases , A. baumannii


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