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JAC Advance Access originally published online on December 1, 2006
Journal of Antimicrobial Chemotherapy 2007 59(2):301-304; doi:10.1093/jac/dkl482
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Differences in biofilm development and antibiotic susceptibility among Streptococcus pneumoniae isolates from cystic fibrosis samples and blood cultures

María García-Castillo, María Isabel Morosini, Aránzazu Valverde, Felisa Almaraz, Fernando Baquero, Rafael Cantón and Rosa del Campo*

Servicio de Microbiología, Hospital Universitario Ramón y Cajal Ctra. Colmenar Km 9.1, Madrid 28034, Spain

Received 9 August 2006; returned 12 September 2006; revised 24 October 2006; accepted 3 November 2006

*Corresponding author. Tel: +34-91-3368542; Fax: +34-91-3368809; E-mail: rosacampo{at}yahoo.com

Objectives: To compare the capability of biofilm development between Streptococcus pneumoniae isolates from cystic fibrosis (CF) respiratory samples and those from non-CF blood cultures. Antibiotic susceptibility of biofilm-forming isolates, as well as differences between antibiotic susceptibility of sessile cells [minimum biofilm inhibitory concentration (MBIC)] and their planktonic counterparts (conventional MIC), were also assessed.

Methods: Biofilm formation was performed using a microtitre method in 20 CF and 22 non-CF blood culture S. pneumoniae isolates.

Results and conclusions: Biofilm formation occurs more frequently among S. pneumoniae isolates from CF (80%) than among non-CF blood culture isolates (50%) (P = 0.04). Moreover MBICs were significantly higher than conventional planktonic MICs among CF but not among non-CF blood isolates, suggesting a high adaptability of CF strains to form biofilms in adverse conditions.

Keywords: S. pneumoniae , minimum biofilm inhibitory concentrations , CF


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