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JAC Advance Access originally published online on July 12, 2006
Journal of Antimicrobial Chemotherapy 2006 58(3):678-679; doi:10.1093/jac/dkl261
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

In vitro effects of penicillin and telithromycin on the expression of Streptococcus pneumoniae capsule

Itzhak Brook* and Jeffrey N. Hausfeld

Departments of Pediatrics and Medicine, Georgetown University and George Washington University, Schools of Medicine 4431 Albemarle St NW, Washington, DC, USA

Received 6 April 2006; returned 2 May 2006; revised 2 May 2006; accepted 1 June 2006

*Corresponding author. Tel: +1-301-295-2698; Fax: +1-253-981-8709; E-mail: ib6{at}georgetown.edu

Objective: To evaluate the effects of subinhibitory concentrations of penicillin and telithromycin on capsular formation by Streptococcus pneumoniae.

Methods: A total of 60 isolates of S. pneumoniae, 20 susceptible, 20 intermediately resistant and 20 resistant to penicillin, were studied. All isolates were susceptible to telithromycin.

Results: All isolates were capsulate when grown without antibiotics. Encapsulation was lower after incubation with telithromycin as compared with penicillin in isolates susceptible to penicillin (20% versus 75%), in those intermediately resistant to penicillin (25% versus 95%) and in isolates fully resistant to penicillin (15% versus 100%) (P < 0.01).

Conclusions: Telithromycin appears to be superior to penicillin in reducing the expression of the capsule by S. pneumoniae.

Keywords: S. pneumoniae , capsular formation , resistance


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