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JAC Advance Access originally published online on July 24, 2006
Journal of Antimicrobial Chemotherapy 2006 58(3):575-579; doi:10.1093/jac/dkl290
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

In vitro inhibitory effect of antituberculosis drugs on clinical and environmental strains of Coccidioides posadasii

Rossana de Aguiar Cordeiro1–,3,*, Raimunda Sâmia Nogueira Brilhante1,2, Marcos Fábio Gadelha Rocha1,4, Maria Auxiliadora Bezerra Fechine1, Zoilo Pires de Camargo5 and José Júlio Costa Sidrim1,2

1 Medical Mycology Specialized Center, Federal University of Ceará Fortaleza, Ceará, Brazil 2 Post-graduation Program in Medical Sciences, Federal University of Ceará Fortaleza, Ceará, Brazil 3 Department of Biological Science, State University of Ceará Fortaleza, Ceará, Brazil 4 Post-graduation Program in Veterinary Science, State University of Ceará Fortaleza, Ceará, Brazil 5 Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo São Paulo, Brazil

Received 26 February 2006; returned 12 April 2006; revised 22 May 2006; accepted 23 June 2006

*Corresponding author. Tel: +55-85-214-2853; Fax: +55-85-295-1736; E-mail: ross{at}uece.br

Objectives: The aim of the present study was to evaluate the in vitro effect of the first-line antimicrobial drugs for pulmonary tuberculosis against the fungal pathogen Coccidioides posadasii.

Methods: The in vitro activities of rifampicin, isoniazid, pyrazinamide and ethambutol against clinical and environmental strains of C. posadasii were determined in accordance with the CSLI M38-A macrodilution method. The antimicrobials were tested alone or in combinations of two or more drugs.

Results: With the exception of pyrazinamide, all of the tested drugs interfered with the in vitro growth of C. posadasii. The 2 day MIC ranges of the tested drugs were as follows: rifampicin 1060–4250 mg/L; isoniazid ≤250 mg/L; ethambutol ≤620 mg/L. Pronounced in vitro synergism was demonstrated for combined antituberculosis drugs. The combination of rifampicin plus pyrazinamide was the only one that did not inhibit fungal growth.

Conclusions: The present study showed that the first-line antituberculosis drugs, alone or in combinations, interfered with the vegetative growth of C. posadasii strains in vitro. Further studies in a murine model will need to be conducted in order to evaluate the in vivo effect of antituberculosis drugs on Coccidioides spp.

Keywords: susceptibility testing , coccidioidomycosis , pulmonary tuberculosis , Brazil


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