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JAC Advance Access originally published online on May 15, 2006
Journal of Antimicrobial Chemotherapy 2006 58(1):133-139; doi:10.1093/jac/dkl190
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Endothelial function in HIV-infected patients with low or mild cardiovascular risk

Juan José Ríos Blanco1,*, Inés Suárez García1, Jorge Gómez Cerezo1, José María Peña Sánchez de Rivera1, Pilar Moreno Anaya2, Pilar García Raya2, Juan González García1, José Ramón Arribas López1, Francisco Javier Barbado Hernández1 and Juan José Vázquez Rodríguez1

1 Department of Internal Medicine, Hospital Universitario La Paz Madrid, Spain 2 Department of Radiology, Hospital Universitario La Paz Madrid, Spain

Received 17 January 2006; returned 28 February 2006; revised 13 April 2006; accepted 18 April 2006

*Corresponding author. Tel: +34-630064677; Fax: +34-917290033; E-mail: juanjo.rios{at}gmail.com

Background: Highly active antiretroviral therapy for HIV-infected patients is associated with metabolic side effects, which could cause an increased cardiovascular risk in these patients. Non-invasive study of endothelial function by brachial artery ultrasound can detect subclinical atherosclerosis. Several studies have assessed endothelial function in HIV-infected patients with associated cardiovascular risk factors.

Objectives: The aim of this study is to determine endothelial function in HIV-infected patients under antiretroviral therapy with low or mild coronary risk and lipid levels within the normal range.

Methods: Transversal study including 28 HIV-infected adults (15 receiving antiretroviral therapy and 13 naive) with low or mild cardiovascular risk and 12 healthy controls. Subjects with diabetes mellitus, hypertension, cardiovascular disease, obesity, high cholesterol or high triglyceride levels were excluded. Endothelial function was determined with flow-mediated dilation (FMD) of the brachial artery by ultrasound study.

Results: Treated HIV-infected patients had significantly lower FMD (5.93 ± 3.56) than healthy controls (10.64 ± 3.08, P = 0.008). Naive patients had an intermediate FMD, but this was not statistically significant.

Conclusions: HIV-infected patients receiving antiretroviral therapy who have low or mild cardiovascular risk and lipid levels within the normal range have endothelial dysfunction compared with healthy controls.

Keywords: atherosclerosis , risk factors , antiretroviral therapy


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