JAC Advance Access originally published online on April 20, 2006
Journal of Antimicrobial Chemotherapy 2006 57(6):1251-1254; doi:10.1093/jac/dkl130
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Comparison of mortality of patients with Acinetobacter baumannii bacteraemia receiving appropriate and inappropriate empirical therapy
1 Alfa Institute of Biomedical Sciences (AIBS) Athens, Greece 2 Department of Medicine, Henry Dunant Hospital Athens, Greece 3 Department of Medicine, Tufts University School of Medicine Boston, MA, USA 4 Department of Microbiology, Henry Dunant Hospital Athens, Greece
Received 20 January 2006; returned 24 February 2006; revised 10 March 2006; accepted 20 March 2006
*Correspondence address. Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Greece. Tel: +30-694-611-0000; Fax: +30-210-683-9605; E-mail: m.falagas{at}aibs.gr
Objectives: To evaluate the effect of inappropriate empirical antimicrobial treatment on the mortality of patients with Acinetobacter baumannii bacteraemia.
Methods: Retrospective cohort study of patients with A. baumannii bacteraemia hospitalized at the Henry Dunant hospital from January 2002 to December 2004.
Results: Among 40 patients with A. baumannii bacteraemia, 22 (55%) and 18 (45%) received inappropriate and appropriate antibiotic therapy, respectively, during the 3 day period after obtaining the blood culture(s) from which the pathogen was isolated. Failure to cure the infection was more common in the first group [16/22 patients (72.7%) versus 5/18 (27.8%), P = 0.005]. Although without statistical significance, probably due to the small number of studied patients, considerably increased mortality was noted in the first group compared with the second group [13/22 patients (59.1%) versus 6/18 (33.3%), P = 0.10].
Conclusions: A. baumannii bacteraemia was associated with worse outcome regarding the cure of infection in patients who received inappropriate empirical antimicrobial treatment compared with those who received appropriate treatment.
Keywords: appropriate therapy , inadequate therapy , Gram-negative bacteria , bloodstream infections , antimicrobial treatment
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