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JAC Advance Access originally published online on April 14, 2006
Journal of Antimicrobial Chemotherapy 2006 57(6):1231-1234; doi:10.1093/jac/dkl132
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb

Yaya Rukayadi1,2, Dongeun Yong3 and Jae-Kwan Hwang1,*

1 Department of Biotechnology & Bioproducts Research Center (BRC), Yonsei University 134 Sinchon-dong, Seodaemun-gu, Seoul 120-749, Korea 2 Research Center for Bioresources and Biotechnology, Bogor Agricultural University Bogor 16880, Indonesia 3 Department of Laboratory Medicine & Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Yonsei University Seoul 120-749, Korea

Received 30 July 2005; returned 19 September 2005; revised 15 March 2006; accepted 20 March 2006

*Corresponding author. Tel: +82-2-2123-5881; Fax: +82-2-362-7265; E-mail: jkhwang{at}yonsei.ac.kr

Objectives: Xanthorrhizol, isolated from the methanol extract of Curcuma xanthorrhiza Roxb., was investigated for its anticandidal activity using six Candida species.

Methods: The in vitro susceptibility tests for xanthorrhizol were carried out in terms of MIC and minimal fungicidal concentration (MFC) using the NCCLS M27-A2 broth microdilution method. Time–kill curves were determined to assess the correlation between MIC and fungicidal activity of xanthorrhizol at concentrations ranging from 0 MIC to 4x MIC.

Results: All Candida species showed susceptibility to xanthorrhizol in the MIC range 1.0–15.0 mg/L for Candida albicans, 1.0–10 mg/L for Candida glabrata, 2.0–8.0 mg/L for Candida guilliermondii, 2.5–7.5 mg/L for Candida krusei, 2.5–25 mg/L for Candida parapsilosis and 2.0–8.0 mg/L for Candida tropicalis. Time–kill curves demonstrated that xanthorrhizol was able to kill the Candida strains with MFCs of 20 mg/mL, 15 mg/mL, 12.5 mg/mL, 10 mg/L, 30 mg/mL and 10 mg/L for C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis and C. tropicalis, respectively.

Conclusions: The potent anticandidal activity of xanthorrhizol may support the use of C. xanthorriza for the treatment of candidiasis.

Keywords: C. xanthorriza , MIC , MFC , antifungals


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