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JAC Advance Access originally published online on February 3, 2006
Journal of Antimicrobial Chemotherapy 2006 57(4):720-723; doi:10.1093/jac/dkl007
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis

Peter Gerber1, Armin Stucki2, Fernando Acosta3, Marianne Cottagnoud3 and Philippe Cottagnoud2,*

1 Clinic of Pneumology, Inselspital, Bern, Switzerland; 2 Department of Internal Medicine, Inselspital, Bern, Switzerland; 3 Clinic of Internal Medicine, Spital Bern-Ziegler, Bern, Switzerland

* Corresponding author. Tel: +41-31-632-34-72; Fax: +41-31-632-38-47; E-mail: pcottagn{at}insel.ch

Objectives: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges

Results: Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (–4.54 ± 1.12 log10/mL for daptomycin versus –3.43 ± 1.17 log10/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was ~5% and ~2% into non-inflamed meninges.

Conclusions: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.

Keywords: bacterial meningitis , treatment , S. aureus , cyclic lipopeptide


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