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JAC Advance Access originally published online on February 28, 2006
Journal of Antimicrobial Chemotherapy 2006 57(4):589-608; doi:10.1093/jac/dkl017
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Review

Guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK

Curtis G. Gemmell1, David I. Edwards2, Adam P. Fraise3, F. Kate Gould4, Geoff L. Ridgway5, Rod E. Warren6,* on behalf of the Joint Working Party of the British Society for Antimicrobial Chemotherapy, Hospital Infection Society and Infection Control Nurses Association

1 Department of Bacteriology, Royal Infirmary, 84-86 Castle Street, Glasgow G4 0SF, Scotland, UK; 2 39 Wallenger Avenue, Gidea Park, Romford, London RM2 6EP, UK; 3 Department of Medical Microbiology, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK; 4 Department of Microbiology, Freeman Hospital, Freeman Road, High Heaton, Newcastle-upon-Tyne NE7 7DN, UK; 5 Department of Health, Wellington House, 133–155 Waterloo Road, London SE1, UK; 6 Department of Microbiology, Royal Shrewsbury Hospital, Mytton Oak Road, Shrewsbury SY3 8XQ, UK

* Corresponding author. Tel: +44-01743-261161; Fax: +44-01743-261165; E-mail: rod.warren{at}rsh.nhs.uk

These evidence-based guidelines have been produced after a literature review of the treatment and prophylaxis of methicillin-resistant Staphylococcus aureus (MRSA) infection. The guidelines were further informed by antibiotic susceptibility data on MRSA from the UK. Recommendations are given for the treatment of common infections caused by MRSA, elimination of MRSA from carriage sites and prophylaxis of surgical site infection. There are several antibiotics currently available that are suitable for use in the management of this problem and potentially useful new agents are continuing to emerge.

Keywords: methicillin , MRSA guidelines , evidence-based guidelines , meticillin


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