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JAC Advance Access originally published online on January 12, 2006
Journal of Antimicrobial Chemotherapy 2006 57(3):506-510; doi:10.1093/jac/dki486
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Decreased susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus: a 20 year study in a large French teaching hospital, 1983–2002

Jérôme Robert*, Roland Bismuth and Vincent Jarlier

Université Pierre et Marie Curie-Paris6; AP-HP, Hôpital Pitié-Salpêtrière, Laboratoire de Bactériologie-Hygiène, Paris, F75013, France

Received 19 September 2005; returned 11 November 2005; revised 9 December 2005; accepted 15 December 2005

* Corresponding author. Tel: +33-1-40-77-97-46; Fax: +33-1-45-82-75-77; E-mail: jrobert{at}chups.jussieu.fr

Objectives: To assess the evolution of glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in a large French teaching hospital from 1983 to 2002.

Methods: Determination of glycopeptide MICs by using the Etest method in Mueller–Hinton agar on a sample of randomly selected MRSA strains.

Results: A total of 1445 MRSA strains were tested, and one vancomycin-intermediate MRSA (VISA) and 31 teicoplanin-intermediate MRSA (TISA) strains were detected. The first strains were detected in 1985, and all strains were gentamicin resistant (GR). None of the gentamicin-susceptible strains had a glycopeptide MIC > 3 mg/L. In addition, there was a significant increase in glycopeptide MIC geometric means over the years, and this increase was higher for teicoplanin than for vancomycin.

Conclusions: The higher increase in teicoplanin MICs, and the good correlation between vancomycin and teicoplanin MICs, suggests systematic determination of teicoplanin MIC to screen for abnormal glycopeptide susceptibility among GR-MRSA.

Keywords: S. aureus , vancomycin , teicoplanin , GISA , gentamicin


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