JAC Advance Access originally published online on October 18, 2005
Journal of Antimicrobial Chemotherapy 2005 56(6):1163-1165; doi:10.1093/jac/dki375
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Pharmacokinetics of imipenem in healthy volunteers following administration by 2 h or 0.5 h infusion
Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90110, Thailand
Received 20 June 2005; returned 4 August 2005; revised 12 September 2005; accepted 19 September 2005
* Corresponding author. Tel/Fax: +66-74-429385; E-mail: sutep.j{at}psu.ac.th
Objectives: The aim of this study was to demonstrate the t > MIC of 0.5 and 1 g of imipenem when administered by 2 h infusion every 6 h compared with 0.5 g of imipenem when administered by 0.5 h infusion every 6 h.
Methods: The study was a randomized three-way crossover study with a 30 h wash-out period in eight healthy volunteers. Each subject received imipenem in three regimens: (i) a 0.5 h infusion of 0.5 g every 6 h for three doses; (ii) a 2 h infusion of 0.5 g every 6 h for three doses; and (iii) a 2 h infusion of 1 g every 6 h for three doses.
Results: Following 0.5 h infusion of 0.5 g, the percentages of time above four times an MIC of 4, 2 and 1 mg/L were 21.5 ± 2.2%, 38.6 ± 3.5% and 57.5 ± 4% of a 6 h interval, respectively. For the 2 h infusion of 0.5 g, the percentages of time above four times an MIC of 4, 2 and 1 mg/L were 26.9 ± 8.5%, 48.0 ± 3.5% and 65.4 ± 3.2% of a 6 h interval, respectively. For the 2 h infusion of 1 g, the percentages of time above four times an MIC of 4, 2 and 1 mg/L were 51.6 ± 5.4%, 67.8 ± 4.5% and 87.8 ± 5.6% of a 6 h interval, respectively.
Conclusions: A 2 h infusion resulted in a greater t > MIC than those after a 0.5 h infusion and intermittent infusion may be a useful mode of administration of imipenem in tropical countries.
Keywords: pharmacodynamics , ß-lactams , carbapenems
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