Skip Navigation


JAC Advance Access originally published online on July 6, 2005
Journal of Antimicrobial Chemotherapy 2005 56(2):262-264; doi:10.1093/jac/dki237
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
56/2/262    most recent
dki237v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yates, C.
Right arrow Articles by Amyes, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yates, C.
Right arrow Articles by Amyes, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Leading article

Extended-spectrum ß-lactamases in non-typhoidal Salmonella spp. isolated in the UK are now a reality: why the late arrival?

Catherine Yates and Sebastian Amyes*

Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, UK

* Corresponding author. Tel: +44-131-650-3163; Fax: +44-131-651-1385; E-mail: s.g.b.amyes{at}ed.ac.uk

In February 2004, we reported the first recognition of the presence of an extended-spectrum ß-lactamase (ESBL) in non-typhoidal Salmonella spp. in the UK; the ß-lactamase was TEM-52. Six months later, an SHV-derived ESBL (SHV-12) was detected in a salmonella strain isolated in York and 6 months after that we have just identified CTX-M-type ß-lactamases in Scottish isolates of Salmonella enterica subsp. enterica serovar Typhimurium and Salmonella Virchow (unpublished results). A very recent retrospective study of UK isolates suggests that they may have been in the population for some years but have gone undetected. Even so, compared with reports of ESBLs in Salmonella spp. elsewhere, these results are suggestive of a delayed emergence of the ESBL phenotype in non-typhoidal Salmonella spp. in the UK. Should the British congratulate themselves on warding off the emergence of these important resistance mechanisms in Salmonella spp., or is the sudden revelation of three of the major ESBL types a cause for concern?

Keywords: ESBLs , emergence , TEM , CTX-M


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.