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JAC Advance Access originally published online on May 12, 2005
Journal of Antimicrobial Chemotherapy 2005 56(1):236-239; doi:10.1093/jac/dki158
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Risk factors for antibiotic-resistant Escherichia coli isolated from community-acquired urinary tract infections in Dakar, Senegal

Jacques Albert Dromigny1,*, Pierre Nabeth2, Ann Juergens-Behr2 and Jean David Perrier-Gros-Claude1

1 Laboratoire de Microbiologie, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal; 2 Unité d'Epidémiologie, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal

Received 18 February 2005; returned 11 March 2005; revised 13 April 2005; accepted 15 April 2005

* Corresponding author. Tel: +221-839-92-31; Fax: +221-822-70-52; Email: dromigny{at}pasteur.sn

Objectives: To assess overall resistance rates and risk factors for resistance to ampicillin, co-amoxiclav, nalidixic acid, fluoroquinolones and trimethoprim/sulfamethoxazole in Escherichia coli strains isolated from outpatients with acute urinary tract infection in Dakar (Senegal).

Patients and methods: From June 2001 to June 2003, a prospective study was performed among Senegalese outpatients consulting at the Institut Pasteur of Dakar for urine analysis. Evaluated risk factors were: age, gender, prior hospitalization, antibiotic exposure, urinary tract infection and urinary catheter.

Results: A total of 398 non-duplicate, consecutive, biologically significant E. coli were isolated. The levels of antibiotic resistance in Dakar appeared dramatic and worrisome with resistance rates ranging from 18.6% for fluoroquinolones to 73.6% for ampicillin. With the exception of the presence of urinary catheter, the risk factors identified were consistent with data previously reported in developed countries.

Conclusions: We hope our results will assist medical authorities in the development of appropriate control strategies.

Keywords: antimicrobial resistance , multivariate analysis , Enterobacteriaceae


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