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JAC Advance Access originally published online on October 27, 2004
Journal of Antimicrobial Chemotherapy 2004 54(6):1134-1138; doi:10.1093/jac/dkh471
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JAC vol.54 no.6 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved

Antibiotic susceptibility of 65 isolates of Burkholderia pseudomallei and Burkholderia mallei to 35 antimicrobial agents

F. M. Thibault1,*, E. Hernandez2, D. R. Vidal1, M. Girardet2 and J.-D. Cavallo2

1 Centre de Recherches du Service de Santé des Armées Emile Pardé, Département de Biologie des Agents Transmissibles, 24 Avenue des Maquis du Grésivaudan, B.P. 87, F-38702 La Tronche; 2 Service de Biologie Médicale, Hôpital d'Instruction des Armées Begin, 69 Avenue de Paris, F-94160 Saint-Mandé, France

* Corresponding author. Tel: +33-4-76-63-69-20; Fax: +33-4-76-63-69-17; Email: fthibault{at}crssa.net

Objectives: Fifty isolates of Burkholderia pseudomallei and 15 isolates of Burkholderia mallei were tested for their susceptibilities to 35 antimicrobial agents, including agents not previously tested against these bacteria.

Methods: MICs were determined by agar dilution in Mueller–Hinton medium.

Results: Among the antibiotics tested, lower MICs were obtained with imipenem, ceftazidime, piperacillin, piperacillin/tazobactam, doxycycline and minocycline. Fluoroquinolones and aminoglycosides had poor activities. A single clinical isolate of B. pseudomallei was resistant to ceftazidime, co-amoxiclav and doxycycline but remained susceptible to imipenem.

Conclusions: Although B. mallei MICs are often lower, the overall results underline the importance of resistance in both species. The susceptibilities measured are consistent with the current recommendations for the treatment of B. pseudomallei and B. mallei infections.

Keywords: melioidosis , glanders , MICs , resistance , biowarfare


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