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JAC Advance Access originally published online on September 3, 2004
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Journal of Antimicrobial Chemotherapy 2004 54(4):840-843; doi:10.1093/jac/dkh414
JAC vol.54 no.4 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved

Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: a randomized, multicentre, open-label, prospective study

José Luis Arredondo-García1,{dagger}, Ricardo Figueroa-Damián1, Alejandro Rosas2, Arturo Jáuregui3,{ddagger}, Mauricio Corral4, Alexis Costa5, Roberto Mauricio Merlos6, Antonio Ríos-Fabra7, Carlos F. Amábile-Cuevas8,*, Gerardo M. Hernández-Oliva9, Jorge Olguín9 and Oscar Cardeñosa-Guerra10 on behalf of the uUTI Latin American Study Group§

1 Instituto Nacional de Perinatología, Mexico City; 2 Hospital General de México, Mexico City; 3 Hospital Clínica del Parque, Chihuahua; 8 Fundación Lusara, Apartado Postal 102-006, 08930, Mexico City; 9 Bayer de México, Dirección Médica, Mexico City, Mexico; 4 Hospital Eugenio Espejo, Quito; 5 Hospital del Sur, Quito, Ecuador; 6 Hospital de Maternidad, San Salvador, El Salvador; 7 Hospital Vargas de Caracas, Caracas, Venezuela; 10 Química Farmacéutica Bayer, Barcelona, Spain

* Corresponding author. Tel/Fax: +52-55-52195855; Email: carlos.amabile{at}lusara.org

Objective: To compare the bacteriological and clinical efficacy of three treatments for uncomplicated cystitis in ambulatory pre-menopausal women: ciprofloxacin 250 mg orally twice daily for 3 days, trimethoprim/sulfamethoxazole 160/800 mg orally twice daily for 7 days, and norfloxacin 400 mg orally twice daily for 7 days.

Materials and methods: A total of 455 women were randomly assigned to three treatment groups: 151 received ciprofloxacin, 150 received trimethoprim/sulfamethoxazole, and 154 received norfloxacin. Bacteriological cure and clinical resolution were evaluated 5–9 days and 4–6 weeks after completion of treatment.

Results: There was no significant difference among the three treatment groups: overall efficacy ranged from 78.5% for the trimethoprim/sulfamethoxazole group, to 84.5% for the ciprofloxacin group. The highest overall incidence of drug-related adverse effects occurred in the trimethoprim/sulfamethoxazole patients.

Conclusions: These data indicate that a 3 day treatment with ciprofloxacin is at least as clinically and bacteriologically effective as 7 day treatments with trimethoprim/sulfamethoxazole and norfloxacin for uncomplicated lower urinary tract infections.

Keywords: fluoroquinolones , clinical trials , cystitis , Latin America


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S. Nys, T. van Merode, A. I. M. Bartelds, and E. E. Stobberingh
Urinary tract infections in general practice patients: diagnostic tests versus bacteriological culture
J. Antimicrob. Chemother., May 1, 2006; 57(5): 955 - 958.
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