JAC Advance Access originally published online on September 16, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal of Antimicrobial Chemotherapy 2004 54(4):744-754; doi:10.1093/jac/dkh422
JAC vol.54 no.4 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved
A European survey of antimicrobial susceptibility among zoonotic and commensal bacteria isolated from food-producing animals
1 EASSA Study Group, c/o CEESA, 1, Rue Defacqz, Brussels; 4 Fort Dodge Animal Health, Louvain-la-Neuve; 6 European Animal Health Study Centre (CEESA), Brussels, Belgium; 2 Bywater Consultancy, Clungunford; 3 Pfizer Animal Health, Sandwich; 7 Inveresk Research, Tranent; 12 Consultant, Wye, UK; 5 Bayer HealthCare AG, Animal Health Division, Leverkusen; 10 Intervet Animal Health, Schwabenheim, Germany; 8 Elanco Animal Health, Greenfield, IN; 9 Schering Plough Animal Health, Kenilworth, NJ, USA; 11 Vetoquinol Animal Health, Lure, France
* Corresponding author. Tel: +44-1547-540-563; Fax: +44-1547-540-307; Email: rbywater{at}onetel.com
Objective: To study antimicrobial resistance in zoonotic bacteria isolated from food animals in different countries using uniform methodology.
Methods: Samples were taken at slaughter from chickens, pigs and cattle in four EU countries per host. Escherichia coli (indicator organism; n=2118), Salmonella spp. (n=271) and Campylobacter spp. (n=1325) were isolated in national laboratories and MICs tested in a central laboratory against, where appropriate, ampicillin, cefepime, cefotaxime, ciprofloxacin, chloramphenicol, erythromycin, gentamicin, nalidixic acid, streptomycin, tetracycline and trimethoprim/sulfamethoxazole.
Results: Isolation rates were high for E. coli, low for Salmonella and intermediate for Campylobacter. MIC results showed resistance prevalence varied among compounds, hosts and countries. For E. coli and Salmonella, resistance to newer compounds (cefepime, cefotaxime, ciprofloxacin) was absent or low, but to older compounds (except gentamicin), resistance was variable and higher. E. coli isolates from Sweden showed low resistance, whereas among isolates from Spain (pigs), resistance to ampicillin, chloramphenicol, streptomycin, tetracycline and trimethoprim/sulfamethoxazole was higher; the UK, France, the Netherlands, Germany, Italy and Denmark were intermediate. For Campylobacter spp. isolates from chickens, nalidixic acid and ciprofloxacin resistance was >30% in France and the Netherlands, >6% in the UK and zero in Sweden. Nalidixic acid resistance was high in cattle (20%–64%), whereas ciprofloxacin resistance was markedly lower in cattle, variable in pigs (3%–21%) and highest in Sweden. Generally, Campylobacter coli was more resistant than Campylobacter jejuni.
Conclusion: Antimicrobial resistance among enteric organisms in food animals varied among countries, particularly for older antimicrobials, but resistance to newer compounds used to treat disease in humans was generally low.
Keywords: zoonotic , enteric organisms , food animals , antibiotics , resistance , surveillance
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. de Jong, R. Bywater, P. Butty, E. Deroover, K. Godinho, U. Klein, H. Marion, S. Simjee, K. Smets, V. Thomas, et al. A pan-European survey of antimicrobial susceptibility towards human-use antimicrobial drugs among zoonotic and commensal enteric bacteria isolated from healthy food-producing animals J. Antimicrob. Chemother., April 1, 2009; 63(4): 733 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Haas, A. Essig, E. Bartelt, and S. Poppert Detection of Resistance to Macrolides in Thermotolerant Campylobacter Species by Fluorescence In Situ Hybridization J. Clin. Microbiol., November 1, 2008; 46(11): 3842 - 3844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. V. Piddock, D. Griggs, M. M. Johnson, V. Ricci, N. C. Elviss, L. K. Williams, F. Jorgensen, S. A. Chisholm, A. J. Lawson, C. Swift, et al. Persistence of Campylobacter species, strain types, antibiotic resistance and mechanisms of tetracycline resistance in poultry flocks treated with chlortetracycline J. Antimicrob. Chemother., August 1, 2008; 62(2): 303 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Miranda, B. I. Vazquez, C. A. Fente, J. Barros-Velazquez, A. Cepeda, and C. M. Franco Evolution of Resistance in Poultry Intestinal Escherichia coli During Three Commonly Used Antimicrobial Therapeutic Treatments in Poultry Poult. Sci., August 1, 2008; 87(8): 1643 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Quinn, J.-M. Bolla, J.-M. Pages, and S. Fanning Antibiotic-resistant Campylobacter: could efflux pump inhibitors control infection? J. Antimicrob. Chemother., June 1, 2007; 59(6): 1230 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hakkinen, H. Heiska, and M.-L. Hanninen Prevalence of Campylobacter spp. in Cattle in Finland and Antimicrobial Susceptibilities of Bovine Campylobacter jejuni Strains Appl. Envir. Microbiol., May 15, 2007; 73(10): 3232 - 3238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Miflin, J. M. Templeton, and P. J. Blackall Antibiotic resistance in Campylobacter jejuni and Campylobacter coli isolated from poultry in the South-East Queensland region J. Antimicrob. Chemother., April 1, 2007; 59(4): 775 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. D'lima, W. G. Miller, R. E. Mandrell, S. L. Wright, R. M. Siletzky, D. K. Carver, and S. Kathariou Clonal Population Structure and Specific Genotypes of Multidrug-Resistant Campylobacter coli from Turkeys Appl. Envir. Microbiol., April 1, 2007; 73(7): 2156 - 2164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Sawant, N. V. Hegde, B. A. Straley, S. C. Donaldson, B. C. Love, S. J. Knabel, and B. M. Jayarao Antimicrobial-Resistant Enteric Bacteria from Dairy Cattle Appl. Envir. Microbiol., January 1, 2007; 73(1): 156 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gibreel and D. E. Taylor Macrolide resistance in Campylobacter jejuni and Campylobacter coli J. Antimicrob. Chemother., August 1, 2006; 58(2): 243 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Donaldson, B. A. Straley, N. V. Hegde, A. A. Sawant, C. DebRoy, and B. M. Jayarao Molecular Epidemiology of Ceftiofur-Resistant Escherichia coli Isolates from Dairy Calves. Appl. Envir. Microbiol., June 1, 2006; 72(6): 3940 - 3948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Inglis, M. McConville, and A. de Jong Atypical Helicobacter canadensis Strains Associated with Swine. Appl. Envir. Microbiol., June 1, 2006; 72(6): 4464 - 4471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Kim, D. K. Carver, and S. Kathariou Natural Transformation-Mediated Transfer of Erythromycin Resistance in Campylobacter coli Strains from Turkeys and Swine Appl. Envir. Microbiol., February 1, 2006; 72(2): 1316 - 1321. [Abstract] [Full Text] [PDF]
|
|