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JAC Advance Access originally published online on July 8, 2004
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Journal of Antimicrobial Chemotherapy 2004 54(2):429-434; doi:10.1093/jac/dkh333
JAC vol.54 no.2 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.

Dissemination amongst humans and food products of animal origin of a Salmonella typhimurium clone expressing an integron-borne OXA-30 ß-lactamase

Patrícia Antunes1,2, Jorge Machado3, João Carlos Sousa2 and Luísa Peixe2,*

1 Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, Porto; 2 Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, no. 164, 4050-047 Porto; 3 Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal

* Corresponding author. Tel: +351-22-2078972; Fax: +351-22-2003977; Email: lpeixe{at}ff.up.pt

Objectives: Characterization of the molecular basis for ß-lactam resistance and evaluation of the clonal relatedness among nine isolates of multidrug-resistant Salmonella typhimurium recovered from seven clinical human samples and two pork end products.

Methods: The isolates were examined for susceptibility to antimicrobial agents. The relationships between resistance genes, class 1 integrons, plasmids and isolates were screened by molecular methods such as polymerase chain reaction and restriction fragment length analysis.

Results: A blaOXA-30 gene, located in a class 1 integron, was detected in all isolates. This integron was present on a conjugative plasmid in all but one isolate. By pulsed-field gel electrophoresis, it was determined that all strains share the same chromosomal type.

Conclusions: This study demonstrates the spread of an OXA-30-producing S. typhimurium in Portugal, suggesting dissemination of a resistant clone through the food chain.

Keywords: salmonellosis , food-borne diseases , class 1 integrons , antimicrobial resistance , ß-lactams


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