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JAC Advance Access originally published online on May 18, 2004
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Journal of Antimicrobial Chemotherapy 2004 54(1):240-242; doi:10.1093/jac/dkh270
JAC vol.54 no.1 © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.

Nitroimidazole resistance genes (nimB) in anaerobic Gram-positive cocci (previously Peptostreptococcus spp.)

Maria M. Theron1,*, Marais N. Janse van Rensburg1 and Lynda J. Chalkley2

1 Department of Medical Microbiology (G4), Faculty of Health Sciences, University of the Free State, Bloemfontein; 2 Medical Research Council, Cape Town, South Africa

* Corresponding author. Tel: +27-51-4053648; Fax: +27-51-4443437; Email: gnmbml.md{at}mail.uovs.ac.za

Objectives: To investigate metronidazole resistance and the prevalence of nitroimidazole (nim) genes in clinically isolated anaerobic Gram-positive cocci.

Methods: Metronidazole susceptibility was determined in 99 strains of anaerobic Gram-positive cocci and PCR amplification for the nim gene carried out on 61 strains (metronidazole MIC ≥0.5 mg/L).

Results: The nimB gene was detected in 34% (21/61) of the strains. These included two highly resistant Finegoldia magna strains (MICs >128 mg/L). The nimB gene was, however, also demonstrated in 90% (19/21) of susceptible strains.

Conclusions: Although the nimB gene may be implicated in the high-level metronidazole resistance in 2 F. magna strains, the alarmingly high prevalence of the nimB gene in anaerobic Gram-positive cocci cannot be directly associated with resistance and the possibility of a silent nimB gene should be considered.

Keywords: anaerobic Gram-positive cocci , metronidazole resistance , nim genes


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