Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Goldstein, E. J. C.
Right arrow Articles by Snydman, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldstein, E. J. C.
Right arrow Articles by Snydman, D. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2004) 53, ii29-ii36
© 2004 The British Society for Antimicrobial Chemotherapy

Supplement

Intra-abdominal infections: review of the bacteriology, antimicrobial susceptibility and the role of ertapenem in their therapy

Ellie J. C. Goldstein1,* and David R. Snydman2

1 R. M. Alden Research Laboratory, Santa Monica, and the UCLA School of Medicine, Los Angeles, CA, USA; 2 Departments of Medicine, Pathology and Community Health, Tufts–New England Medical Center and Tufts University School of Medicine, Boston, MA, USA

Abstract

Complicated intra-abdominal infections require a combination of surgery/drainage and antimicrobial therapy that is active against both the aerobic and the anaerobic bacteria that comprise the intestinal flora. Ertapenem, a parenteral carbapenem, is highly resistant to a wide variety of ß-lactamase enzymes, and has a broad spectrum of activity against bacteria associated with community-acquired infections including those of complicated intra-abdominal conditions. This article reviews the bacteriology of complicated intra-abdominal infections, their antimicrobial susceptibility, especially to anaerobes, the utility of animal models in these mixed infections, and the supportive clinical trials and in vitro susceptibility data that show ertapenem to be generally well tolerated and as effective as either piperacillin–tazobactam or ceftriaxone plus metronidazole in the therapy of complicated intra-abdominal infections.

Keywords: Bacteroides fragilis, carbapenems, intra-abdominal abscess, anaerobes, bacteriology

Footnotes

* Correspondence address. R. M. Alden Research Laboratory, 2021 Santa Monica Boulevard, Suite 740E, Santa Monica, CA 90404, USA. Tel: +1-310-315-1511; Fax: +1-310-315-3662; E-mail: EJCGMD{at}aol.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
K. V. d. Santos, J. R. Nicoli, W. A. Martins, S. C. Coutinho, A. C. M. Apolonio, C. G. Diniz, M. A. R. d. Carvalho, and L. d. M. Farias
Comparative activity of ertapenem and piperacillin tazobactam in a murine systemic infection model with Bacteroides fragilis and Escherichia coli
J. Med. Microbiol., November 1, 2007; 56(11): 1576 - 1579.
[Full Text] [PDF]

Home page
 J Med MicrobiolHome page
K. Valeria dos Santos, C. G. Diniz, S. C. Coutinho, A. C. M. Apolonio, L. Geralda de Sousa-Gaia, J. R. Nicoli, L. d. M. Farias, and M. A. Roque de Carvalho
In vitro activity of piperacillin/tazobactam and ertapenem against Bacteroides fragilis and Escherichia coli in pure and mixed cultures
J. Med. Microbiol., June 1, 2007; 56(6): 798 - 802.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
Y. A. Warren, K. L. Tyrrell, D. M. Citron, and E. J. C. Goldstein
Clostridium aldenense sp. nov. and Clostridium citroniae sp. nov. Isolated from Human Clinical Infections.
J. Clin. Microbiol., July 1, 2006; 44(7): 2416 - 2422.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
E. J. C. Goldstein, D. M. Citron, Y. A. Warren, K. L. Tyrrell, C. V. Merriam, and H. Fernandez
In Vitro Activity of Moxifloxacin against 923 Anaerobes Isolated from Human Intra-Abdominal Infections
Antimicrob. Agents Chemother., January 1, 2006; 50(1): 148 - 155.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.