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JAC Advance Access originally published online on April 29, 2004
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Journal of Antimicrobial Chemotherapy (2004) 53, 936-946
© 2004 The British Society for Antimicrobial Chemotherapy

Review

Interaction between HIV-1 and HCV infections: towards a new entity?

Maria Winnock1,*, Dominique Salmon-Céron2, François Dabis1 and Geneviève Chêne1

1 INSERM U593, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux; 2 Department of Internal Medicine, Hôpital Cochin, Paris, France

Since human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share the same modes of transmission, HIV–HCV co-infected patients are relatively common. Until recently, the clinical course of HCV in co-infected patients was overshadowed by the high morbidity and mortality of HIV disease. Recent reductions in morbidity and mortality among HIV-infected patients due to the advent of highly active antiretroviral therapy (HAART), have contributed to the emergence of HCV as a significant viral pathogen in this population. This article reviews the current evidence on the epidemiology and clinical implications of an interaction between HIV-1 and HCV infections.

Keywords: prevalence, epidemiology, fibrosis, liver, HAART

* Corresponding author. Tel: +33-5-57-57-13-93; Fax: +33-5-57-57-11-72; E-mail: Maria.Winnock{at}isped.u-bordeaux2.fr


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[Abstract] [PDF]


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