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JAC Advance Access originally published online on February 18, 2004
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Journal of Antimicrobial Chemotherapy (2004) 53, 620-625
© 2004 The British Society for Antimicrobial Chemotherapy

Spectrum of antibiotic resistance of the Spain14-5 Streptococcus pneumoniae clone over a 22 year period

Emilio Pérez-Trallero1,2,*, José María Marimón1, Alberto Gonzalez1, Diego Vicente1 and José María García-Arenzana on behalf of The Spanish Pneumococcal Infection Study Network§

1 Microbiology Service, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián (Gipuzkoa); 2 Department of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country, San Sebastián, Spain

Received 4 November 2003; returned 23 November 2003; revised 10 December 2003; accepted 11 December 2003

Objective: To study the characteristics and the evolution through time of a single Streptococcus pneumoniae multidrug-resistant international clone.

Methods: From 1981 to 2002, the presence of the multidrug-resistant Spain14-5 clone was studied among the 4201 S. pneumoniae isolated in Gipuzkoa (northern Spain).

Results: Overall, 93 isolates belonging to the Spain14-5 clone were identified. The first isolate of this clone was detected in 1981 and was already resistant to ß-lactams, erythromycin, clindamycin and chloramphenicol. The reference strain from the international collection for this clone was susceptible to macrolides and lincosamides whereas most of the isolates studied, including the first isolate detected in 1981, were resistant to macrolides and had the erm(B) gene encoding macrolide resistance.

Conclusions: The clone was genetically stable through time, was multiresistant since its inception and has recently become highly resistant to fluoroquinolones. The characteristic antibiotic resistance pattern of this clone should include erythromycin resistance.

Keywords: multiresistance, PFGE, MLST, fluoroquinolone resistance, macrolide resistance

* Corresponding author. Tel: +34-94-30-07046; Fax: +34-94-30-07063; E-mail: mikrobiol{at}terra.es

§ Participants in the Spanish Pneumococcal Infection Study Network are listed in the Acknowledgements.


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