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JAC Advance Access originally published online on January 16, 2004
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Journal of Antimicrobial Chemotherapy (2004) 53, 325-328
© 2004 The British Society for Antimicrobial Chemotherapy

Serum and sputum concentrations following the oral administration of linezolid in adult patients with cystic fibrosis

Dinesh Saralaya1, Daniel G. Peckham1,*, Bill Hulme1, Caroline M. Tobin2, Miles Denton3, Steve Conway1 and Christine Etherington1

1 Regional Adult Cystic Fibrosis Unit, Seacroft Hospital, York Road, Leeds LS14 6UH; 2 Department of Microbiology, Southmead Hospital, Bristol BS10 5NB; 3 Department of Microbiology, Leeds Teaching Hospitals Trust, Leeds LS1 3EX, UK

Received 11 July 2003; returned 10 October 2003; revised 23 October 2003; accepted 16 November 2003

Objectives: Linezolid is a new oxazolidinone antibiotic with efficacy against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). In this study, we have determined the serum and sputum linezolid concentrations in adults with cystic fibrosis (CF) following oral drug administration.

Methods: Eleven adult patients with CF were recruited. Subjects received 600 mg of linezolid orally every 12 h for a total of six doses. Serum and sputum levels were measured just before and at 2 h after the final dose of linezolid. A further serum level was measured at 4 h.

Results: Ten adult patients completed the study. Mean (S.D.) serum linezolid concentrations were 2.3 mg/L (1.5) at 12 h following the fifth dose. At 2 and 4 h following the sixth dose, concentrations were 13.5 (4.3) and 8.1 (3.3). Mean (S.D.) linezolid sputum concentrations were 3.6 (2.1) and 17.4 (7.2) mg/L at 0 and 2 h following drug administration.

Conclusions: The oral administration of linezolid results in good sputum penetration in patients with CF. Mean levels exceed the required MIC for the treatment of MRSA for >80% of the dosing period for serum and the majority of the dosing period for sputum.

Keywords: oxazolidinones, MRSA, serum levels, pancreatic insufficient

* Corresponding author. Tel: +44-113-2063513; Fax: +44-113-2063738; E-mail:daniel.peckham{at}btinternet.com


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