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JAC Advance Access originally published online on December 19, 2003
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Journal of Antimicrobial Chemotherapy (2004) 53, 140-143
© 2004 The British Society for Antimicrobial Chemotherapy

Leading Article

Available clinical markers of treatment outcome integrated in mathematical models to guide therapy in HIV infection

Elisabeta Vergu*, Alain Mallet and Jean-Louis Golmard

INSERM U436, Mathematical and Statistical Modelling in Biology and Medicine, CHU Pitié-Salpêtrière, Paris, France

Because treatment failure in many HIV-infected persons may be due to multiple causes, including resistance to antiretroviral agents, it is important to better tailor drug therapy to individual patients. This improvement requires the prediction of treatment outcome from baseline immunological or virological factors, and from results of resistance tests. Here, we review briefly the available clinical factors that have an impact on therapy outcome, and discuss the role of a predictive modelling approach integrating these factors proposed in a previous work. Mathematical and statistical models could become essential tools to address questions that are difficult to study clinically and experimentally, thereby guiding decisions in the choice of individualized drug regimens.

Keywords: resistance tests, modelling, therapy outcome

* Correspondence address. INSERM U436, 91 boulevard de l’Hôpital, Paris cedex 13, France. Tel: +33-1-40-77-98-54; Fax: +33-1-45-85-15-29; E-mail: eve{at}biomath.jussieu.fr


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