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JAC Advance Access originally published online on November 25, 2003
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Journal of Antimicrobial Chemotherapy (2004) 53, 53-57
© 2004 The British Society for Antimicrobial Chemotherapy

Review

Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1

Dan Turner, Bluma Brenner and Mark A. Wainberg*

McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2

Highly active antiretroviral therapy has significantly improved HIV-related morbidity and mortality, and nucleoside reverse transcriptase inhibitors remain an essential component of treatment. However, the emergence of HIV-1 mutated strains that are resistant to one or more antiretroviral drugs is a leading cause of treatment failure among patients living with HIV/AIDS. These resistant strains may often suffer from a replication disadvantage in comparison with wild-type viruses when grown in the absence of drug pressure and a potential benefit in this regard has been shown for lamivudine-resistant viruses that contain a M184V mutation in reverse transcriptase, as well as for several other drug-resistant viral variants. Interactions between different mutations may complicate the understanding of HIV drug resistance with regard to the likelihood of therapeutic success.

Keywords: HIV, NRTIs, resistance, mutations, antiretroviral drugs, nucleosides, diminished sensitivity, viral fitness

* Corresponding author. Tel: +1-514-340-8260; Fax: +1-514-340-7537; E-mail: mark.wainberg{at}mcgill.ca


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 Antimicrob. Agents Chemother.Home page
M. Ntemgwa, M. A. Wainberg, M. Oliveira, D. Moisi, R. Lalonde, V. Micheli, and B. G. Brenner
Variations in Reverse Transcriptase and RNase H Domain Mutations in Human Immunodeficiency Virus Type 1 Clinical Isolates Are Associated with Divergent Phenotypic Resistance to Zidovudine
Antimicrob. Agents Chemother., November 1, 2007; 51(11): 3861 - 3869.
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