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JAC Advance Access originally published online on December 4, 2003
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Journal of Antimicrobial Chemotherapy (2004) 53, 115-117
© 2004 The British Society for Antimicrobial Chemotherapy

Reversible dilated cardiomyopathy related to amphotericin B therapy

Patrick J. Danaher1,*, Michael K. Cao2, Gregory M. Anstead3, Matthew J. Dolan4 and Caroline C. DeWitt4

1 Department of Infectious Diseases and 2 Department of Cardiology, David Grant USAF Medical Center, Travis AFB, CA 94535; 3 Medical Service, Department of Veterans Affairs Medical Center, South Texas Health Care System, San Antonio, TX 78229; 4 Department of Infectious Diseases,Wilford Hall USAF Medical Center, Lackland AFB, TX 78236, USA

Received 17 June 2003; returned 17 August 2003; revised 3 September 2003; accepted 15 September 2003

We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved after posaconazole was substituted for AmB. It is important to recognize the rare and potentially reversible toxicity of AmB.

Keywords: posaconazole, coccidioidomycosis, Coccidioides immitis

* Correspondence address. Infectious Disease Service, 60MDG/60MDOS/SGOMB, 101 Bodin Circle, Travis AFB, CA 94535-1800, USA. Tel: +1-707-423-5140; Fax: +1-707-423-5058; E-mail: patrick.danaher{at}60mdg.travis.af.mil


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