JAC Advance Access originally published online on December 4, 2003
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Journal of Antimicrobial Chemotherapy (2004) 53, 105-108
© 2004 The British Society for Antimicrobial Chemotherapy
Clonal dissemination of mupirocin-resistant staphylococci in Greek hospitals
1 Department of Microbiology, School of Medicine, University of Thessalia, Papakyriazi 22, Larissa; 2 Department of Microbiology, School of Medicine, University of Patras; 3 Department of Microbiology, General Hospital of Athens G. Genimatas, Athens; 4 Department of Microbiology, General Hospital Asclepeion, Voula, Athens, Greece
Received 23 July 2003; returned 1 September 2003; revised 23 September 2003; accepted 10 October 2003
Objectives: To determine the rates of mupirocin resistance in staphylococci during a 4 year period (1999–2002) in Greece.
Materials: A total of 1200 Staphylococcus aureus and 2760 coagulase-negative staphylococci (CoNS), consecutively collected from four Greek hospitals located in different geographical areas, were tested for susceptibility to mupirocin using the Etest and a reference agar dilution method.
Results: Twenty-four S. aureus (2%) and 532 CoNS (19.2%) were found to be mupirocin-resistant during the study period. High-level mupirocin resistance was detected in 20 S. aureus (1.6%) and in 440 CoNS (15.9%), respectively. No variations in the rates of mupirocin-resistant S. aureus in relation to the year of collection were observed. In contrast, the rate of mupirocin-resistant CoNS increased dramatically from 9% in 1999, to 14% in 2000, 20% in 2001 and reached 33% in 2002. PFGE analysis revealed the presence of one main clone (A) among mupirocin-resistant S. aureus and two main clones (i and a) among Staphylococcus epidermidis isolates.
Conclusions: In Greece, the rate of mupirocin-resistant S. aureus has remained low and steady since 1999. The high rate of mupirocin-resistant CoNS (33%) in 2002 was due mainly to clonal dissemination of epidemic hospital clones.
Keywords: Staphylococcus aureus, Staphylococcus epidermidis, mupirocin resistance, epidemic clones, Greece
* These authors contributed equally to this work.
These authors contributed equally to this work.
¶ Corresponding author. Fax: +30-41-0682508; E-mail: anm{at}otenet.gr
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