Skip Navigation


JAC Advance Access originally published online on November 12, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
52/6/1025    most recent
dkg480v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lu, T.
Right arrow Articles by Drlica, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, T.
Right arrow Articles by Drlica, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2003) 52, 1025-1028
© 2003 The British Society for Antimicrobial Chemotherapy

In vitro activity of C-8-methoxy fluoroquinolones against mycobacteria when combined with anti-tuberculosis agents

Tao Lu and Karl Drlica*

Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA

Received 9 May 2003; returned 5 August 2003; revised 10 September 2003; accepted 25 September 2003

Objectives: To examine the effect of first-line and second-line anti-tuberculosis agents on the ability of fluoroquinolones to kill mycobacteria.

Methods: A clinical isolate of Mycobacterium tuberculosis and a laboratory strain of Mycobacterium smegmatis were grown in liquid medium and treated with a fluoroquinolone in the presence or absence of anti-tuberculosis agents. Bacterial survival was determined by viable colony counts on agar medium.

Results: When moxifloxacin activity was examined in two-drug combinations containing traditional anti-tuberculosis agents, activity was greater than either compound alone with isoniazid, capreomycin and low, but not high, concentrations of rifampicin. Cycloserine contributed no additional activity, and ethambutol interfered with the lethal action of moxifloxacin and gatifloxacin. Experiments with M. smegmatis confirmed that both rifampicin and ethambutol reduce fluoroquinolone lethality. Moreover, ethambutol increased the recovery of fluoroquinolone-resistant mutants newly created by ethyl methanesulphonate treatment.

Conclusions: The intrinsic bactericidal activity of C-8-methoxy fluoroquinolones can be adversely affected by some agents currently used for treatment of tuberculosis.

Keywords: moxifloxacin, gatifloxacin, rifampicin, ethambutol

* Corresponding author. Tel: +1-973-854-3360; E-mail: drlica{at}phri.org


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
J. van den Boogaard, G. S. Kibiki, E. R. Kisanga, M. J. Boeree, and R. E. Aarnoutse
New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development
Antimicrob. Agents Chemother., March 1, 2009; 53(3): 849 - 862.
[Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. Malik and K. Drlica
Moxifloxacin Lethality against Mycobacterium tuberculosis in the Presence and Absence of Chloramphenicol.
Antimicrob. Agents Chemother., August 1, 2006; 50(8): 2842 - 2844.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. Malik, T. Lu, X. Zhao, A. Singh, C. M. Hattan, J. Domagala, R. Kerns, and K. Drlica
Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol
Antimicrob. Agents Chemother., May 1, 2005; 49(5): 2008 - 2014.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.