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JAC Advance Access originally published online on August 13, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 497-499
© 2003 The British Society for Antimicrobial Chemotherapy

In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae

Naoyuki Miyashita*, Hiroshi Fukano, Koichiro Yoshida, Yoshihito Niki and Toshiharu Matsushima

Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan

Received 14 February 2003; returned 15 April 2003; revised 13 June 2003; accepted 17 June 2003

Objectives: To investigate the in vitro activity of cethromycin, a new ketolide, against Chlamydia pneumoniae.

Methods: The in vitro activity of cethromycin against 20 isolates of C. pneumoniae was compared with the activities of telithromycin, erythromycin A, azithromycin and clarithromycin against those isolates.

Results: The MIC at which 90% of the isolates were inhibited and the minimal chlamydiacidal concentration at which 90% of the isolates were killed by cethromycin were both 0.016 mg/L (range 0.016–0.031 mg/L). Cethromycin was the most active antibiotic tested in this study.

Conclusions: Our results appear to indicate that cethromycin is an effective antibiotic that should play some role in the treatment of respiratory tract infections caused by C. pneumoniae.

Keywords: macrolides, telithromycin, community-acquired pneumonia

* Corresponding author. Tel: +81-86-462-1111; Fax: +81-86-462-1199; E-mail: nao{at}med.kawasaki-m.ac.jp


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