JAC Advance Access originally published online on August 13, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 493-496
© 2003 The British Society for Antimicrobial Chemotherapy
Diversity of TEM-52 extended-spectrum ß-lactamase-producing non-typhoidal Salmonella isolates in Korea
1 Department of Laboratory Medicine, 2 Research Institute of Bacterial Resistance, 3 Brain Korea 21 Medical Sciences, Yonsei University College of Medicine, Seoul, 120-752, Korea
Received 25 February 2003; returned 8 May 2003; revised 22 June 2003; accepted 24 June 2003
Objectives: Extended-spectrum ß-lactamase (ESBL)-producing non-typhoidal Salmonella (NTS) isolates in Korea were characterized.
Patients and methods: Five isolates of ESBL-producing NTS were isolated from stool specimens of three infants and two adults with diarrhoea. Two infants acquired the infection in the community, and three other infections were hospital acquired.
Results: The isolates were one each of serovars Saintpaul, Stanley and Agona, and two Enteritidis. Cell sonicates of the isolates hydrolysed cefotaxime more efficiently than ceftazidime, and had ß-lactamase bands of approximate isoelectric points 6.0 and 7.4. Sequencing revealed that the ß-lactamases were TEM-52 and an OXA type. The blaOXA gene was located on a class 1 integron. Cefotaxime resistance, associated with TEM-52, was transferred by conjugation. Identical pulsed-field gel electrophoresis patterns of XbaI-digested genomic DNA were observed in initially ß-lactam-susceptible serovar Agona isolates and subsequent ESBL-producing isolates from an infant, and in two isolates of serovar Enteritidis from two different patients.
Conclusions: This study suggests that TEM-52-producing NTS is spreading both clonally and horizontally in Korea.
Keywords: enteritis, class 1 integron, OXA-type ß-lactamase
* Correspondence address. Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul 120-752, Korea. Tel: +82-2-361-5866; Fax: +82-2-313-0908; E-mail: whonetkor{at}yumc.yonsei.ac.kr
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