JAC Advance Access originally published online on July 15, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 208-213
© 2003 The British Society for Antimicrobial Chemotherapy
Emergence of fluoroquinolone resistance among Bacteroides species
1 Geographic Medicine and Infectious Diseases, Tufts—New England Medical Center, Boston, MA; 2 R. M. Alden Research Laboratories, UCLA Medical Center, Santa Monica, CA; 3 Microbiology, Wadsworth Veteran Administration Hospital, Los Angeles, CA; 4 Microbiology, Duke University Medical Center, Durham, NC; 5 Microbiology, Loyola University Medical Center, Maywood, IL; 6 Microbiology, Carolinas Medical Center, Charlotte, NC; 7 Microbiology, Danbury Hospital, Danbury, CT; 8 Microbiology, Albany Medical Center, Albany, NY; 9 Microbiology, University of Michigan Medical Center, Ann Arbor, MI; 10 Microbiology, Pittsburgh Veterans Administration Medical Center, Pittsburgh, PA, USA
Received 27 January 2003; returned 6 April 2003; revised 29 April 2003; accepted 7 May 2003
Background: Several newer generation fluoroquinolones have demonstrated good in vitro activity against Bacteroides species; particularly when first introduced. However, resistance of Bacteroides to quinolones appears to be increasing.
Materials and methods: From 1994 to 2001, consecutive non-duplicated Bacteroides isolates from clinical specimens in 12 US hospitals were sent to the Tufts anaerobe laboratory for identification and susceptibility testing. NCCLS recommended methodology for testing was employed. Breakpoints of 8 mg/L for trovafloxacin and 4 mg/L for moxifloxacin were used to examine susceptibility trends.
Results: In total, 4434 isolates were analysed. The geometric mean MIC increased significantly for clinafloxacin, trovafloxacin and moxifloxacin. Resistance to trovafloxacin (breakpoint of 8 mg/L) and moxifloxacin (breakpoint of 4 mg/L) increased from 8% to 25% and from 30% to 43%, respectively. Increased resistance was observed for all Bacteroides species, for all sites of isolation, and in 11 of 12 participating hospitals. Bacteroides vulgatus and isolates from decubitus ulcers were associated with increased resistance. During 2001, trovafloxacin and moxifloxacin resistance among blood isolates was 27% and 52%, respectively. The association between increased resistance and year of isolation remained significant after adjustment for hospital, species and site of isolation.
Conclusions: Fluoroquinolone resistance among Bacteroides isolated in the US has markedly increased during the years 1994 to 2001. High rates of resistance among blood isolates are of particular concern.
Keywords: antibiotic resistance, anaerobes
* Corresponding author. Tel: +1-617-636-2345; Fax: +1-617-636-8525; E-mail: YGolan{at}tufts-nemc.org
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