JAC Advance Access originally published online on June 12, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal of Antimicrobial Chemotherapy (2003) 52, 50-55
© 2003 The British Society for Antimicrobial Chemotherapy
Streptococcus pyogenes isolates with characterized macrolide resistance mechanisms in Spain: in vitro activities of telithromycin and cethromycin
Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Ctra. de Colmenar, Km 9,1, 28034 Madrid, Spain
Received 19 February 2003; returned 20 March 2003; revised 31 March 2003; accepted 27 April 2003
The in vitro activities of telithromycin and cethromycin (ABT-773) against 412 Streptococcus pyogenes isolates, consecutively collected in 17 Spanish hospitals from different geographical areas, were evaluated and compared with those of erythromycin A, penicillin G, clindamycin and quinupristin–dalfopristin. With a susceptibility testing breakpoint of ≤1 mg/L for both compounds, 96.1% of isolates were susceptible to telithromycin and 99.8% to cethromycin. Erythromycin non-susceptible isolates (intermediate plus resistant, MIC ≥ 0.5 mg/L) comprised 23% of those tested, and were analysed for the genetic basis of their resistance by PCR. Among these isolates (n = 95), 72.6% harboured mef(A), 8.4%, erm(B), and 3.2%, erm(A), as sole macrolide resistance gene, whereas the presence of mef(A) plus erm(A) (11.6%) or mef(A) plus erm(B) (4.2%) was also observed. Both ketolides displayed a significant in vitro activity against S. pyogenes regardless of the macrolide resistance mechanisms. Nevertheless, in the case of telithromycin, 11 out of 19 of the erm(B)-positive isolates (2.7% of total population) exhibited an MIC range of 4–32 mg/L. According to the present results, telithromycin and cethromycin offer a wide coverage against S. pyogenes isolates in a geographic area with a high incidence of resistance to currently used macrolides.
Keywords: S. pyogenes, ketolides, telithromycin, cethromycin, macrolide resistance
* Corresponding author. Tel: +34-91-336-8330; Fax: +34-91-336-8809; E-mail: rcanton.hrc{at}salud.madrid.org
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Asmah, B. Eberspacher, T. Regnath, and M. Arvand Prevalence of erythromycin and clindamycin resistance among clinical isolates of the Streptococcus anginosus group in Germany J. Med. Microbiol., February 1, 2009; 58(2): 222 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Erdem, J. Ford, D. Johnson, L. Abe, K. Yamaga, and E. Kaplan Erythromycin-Resistant Group A Streptococcal Isolates Collected between 2000 and 2005 in Oahu, Hawaii, and Their emm Types J. Clin. Microbiol., May 1, 2005; 43(5): 2497 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. W. Klaassen and J. W. Mouton Molecular Detection of the Macrolide Efflux Gene: To Discriminate or Not To Discriminate between mef(A) and mef(E) Antimicrob. Agents Chemother., April 1, 2005; 49(4): 1271 - 1278. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Canton, A. Mazzariol, M.-I. Morosini, F. Baquero, and G. Cornaglia Telithromycin activity is reduced by efflux in Streptococcus pyogenes J. Antimicrob. Chemother., April 1, 2005; 55(4): 489 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Szczypa, E. Sadowy, R. Izdebski, and W. Hryniewicz A rapid increase in macrolide resistance in Streptococcus pyogenes isolated in Poland during 1996-2002 J. Antimicrob. Chemother., October 1, 2004; 54(4): 828 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Reinert Clinical efficacy of ketolides in the treatment of respiratory tract infections J. Antimicrob. Chemother., June 1, 2004; 53(6): 918 - 927. [Abstract] [Full Text] [PDF]
|
|