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JAC Advance Access originally published online on June 12, 2003
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Journal of Antimicrobial Chemotherapy (2003) 52, 123-127
© 2003 The British Society for Antimicrobial Chemotherapy

The in vitro activity of daptomycin against Staphylococcus aureus and Enterococcus species

S. S. Richter*, D. E. Kealey, C. T. Murray, K. P. Heilmann, S. L. Coffman and G. V. Doern

Department of Pathology, C606 GH, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa 52242–1009, USA

Received 13 January 2003; returned 7 March 2003; revised 14 April 2003; accepted 15 April 2003

Objective: The purpose of this study was to examine the in vitro activity of daptomycin using an optimal calcium (Ca2+) concentration (50 mg/L) against a diverse collection of enterococcal and Staphylococcus aureus clinical isolates, including glycopeptide-resistant enterococci (GRE) and methicillin-resistant S. aureus (MRSA).

Methods: The activity of daptomycin was compared with the activities of seven other agents against 1483 enterococcal and S. aureus clinical isolates, including 303 GRE and 193 methicillin-resistant S. aureus (MRSA) strains. Susceptibility testing was performed by the NCCLS broth microdilution method, with one exception: Mueller–Hinton (MH) broth was supplemented to a physiological level of 50 mg/L Ca2+ when testing daptomycin. Daptomycin zone diameters were determined by disc diffusion with MH agar plates containing Ca2+ 50 mg/L.

Results: All staphylococcal isolates tested, and the majority of enterococcal isolates (96.5%), would be considered susceptible to daptomycin if the breakpoint previously proposed of ≤2 mg/L was applied. The activity of daptomycin against MRSA and methicillin-susceptible S. aureus was essentially equal. Daptomycin also had similar activity against GRE and glycopeptide-susceptible enterococci. Every S. aureus isolate had a daptomycin zone diameter ≥20 mm, and all of the enterococcal isolates had daptomycin zone diameters ≥17 mm.

Conclusions: Overall, daptomycin showed potent activity against S. aureus and enterococcal isolates, comparable to quinupristin–dalfopristin and linezolid.

Keywords: lipopeptides, staphylococci, enterococci

* Corresponding author. Tel: +1-319-356-2990; Fax: +1-319-356-4916; E-mail: sandra-richter@uiowa.edu


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