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JAC Advance Access originally published online on April 25, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1427-1429
© 2003 The British Society for Antimicrobial Chemotherapy

Efficacy of caspofungin combined with amphotericin B against azole-resistant Candida albicans

Mohammad A. Hossain1, Guadalupe H. Reyes1, Lisa A. Long1, Pranab K. Mukherjee1 and Mahmoud A. Ghannoum1,2,*

1 Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5028; 2 University Hospitals of Cleveland, Cleveland, OH 44106, USA

Received 25 September 2002; returned 1 December 2002; revised 26 February 2003; accepted 26 February 2003

The activity of caspofungin (CFG) combined with amphotericin B (AMB) against azole-resistant Candida albicans was evaluated in vitro (chequerboard) and in vivo (murine). CFG+AMB resulted in positive interactive effects in vitro (fractional inhibitory concentration index 0.75). Compared with untreated controls, CFG+AMB prolonged mouse survival (P = 0.006) and compared with AMB alone, CFG+AMB prolonged mouse survival (P = 0.36); however, the latter difference was not signficant. CFG+AMB treatment significantly reduced kidney cfu compared with untreated controls and CFG-treated groups (P <= 0.05 for both comparisons). In addition, this combination reduced brain cfu significantly compared with untreated controls and AMB-treated mice (P = 0.005 and 0.05, respectively).

Keywords: disseminated candidiasis, antifungal, therapy

* Corresponding author. Tel: +1-216-844-8580; Fax: +1-216-844-1076; E-mail: mag3@po.cwru.edu


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