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JAC Advance Access originally published online on April 14, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1175-1179
© 2003 The British Society for Antimicrobial Chemotherapy

Effects of mupirocin at subinhibitory concentrations on flagella formation in Pseudomonas aeruginosa and Proteus mirabilis

Toshinobu Horii1,2,*, Motoki Morita1,3, Hideaki Muramatsu2,4, Yoshinori Muranaka5, Takashi Kanno1 and Masato Maekawa1

1 Department of Laboratory Medicine, 2 Group of Infection Control Research, 4 Division of Pharmacy, 5 Laboratory for Ultrastructure Research, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192; 3 Daiichi Pure Chemicals, 3-3-1 Koyodai, Ryugasaki 301-0852, Japan

Received 18 April 2002; returned 27 August 2002; revised 25 October 2002; accepted 21 February 2003

Colonization of Pseudomonas aeruginosa at trachea, nares and oropharynx can cause ventilator-acquired pneumonia. To identify beneficial effects of antibiotics on expression of virulence factors related to colonization by such pathogens, we evaluated the effect of mupirocin on flagella formation in P. aeruginosa and on motility and flagella formation in Proteus mirabilis. In P. aeruginosa, subinhibitory concentrations of mupirocin inhibited flagella formation, which was associated with reduced flagellin expression. In P. mirabilis, subinhibitory concentrations of mupirocin dose-dependently suppressed bacterial motility and flagella formation, again with reduced flagellin expression. Our results indicate that subinhibitory concentrations of mupirocin can suppress expression of virulence factors in P. aeruginosa and P. mirabilis.

* Corresponding author. Tel: +81-53-435-2788; Fax: +81-53-435-2794; E-mail: horiihm{at}hama-med.ac.jp


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