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JAC Advance Access originally published online on March 13, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1033-1036
© 2003 The British Society for Antimicrobial Chemotherapy

Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing

Brendan W. Mason1,*, Anthony J. Howard2 and John T. Magee1

1 Public Health Laboratory Service, Communicable Disease Surveillance Centre (Wales), Abton House, Wedal Road, Cardiff CF14 3QX; 2 Department of Medical Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF14 4XW, UK

Received 17 October 2002; returned 4 December 2002; revised 13 December 2002; accepted 3 February 2003

The level of resistance to fusidic acid among community methicillin-susceptible Staphylococcus aureus (MSSA) isolates in the UK and prescriptions for fusidic acid have both doubled over the past 6 years. It is hypothesized that selective pressure arising from topical use of fusidic acid in the community accounts for this increase. A significant correlation was found between prescribing of fusidic acid and resistance at the practice level (Spearman’s rho = 0.46, 95% confidence interval 0.11–0.71, P = 0.01). Further controlled studies are required to determine whether this association is causal.

Keywords: fusidic acid resistance, Staphylococcus aureus, fusidic acid prescribing

* Corresponding author. Tel: +44-29-2052-1997; Fax: +44-29-2052-1987; E-mail: Brendan.mason{at}phls.wales.nhs.uk


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