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JAC Advance Access originally published online on March 13, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 1021-1024
© 2003 The British Society for Antimicrobial Chemotherapy

In vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of Plasmodium falciparum isolates from the Haut-Ogooué region of Gabon

Christiane Atteke1,2,*, Jérôme Mezui Me Ndong2, Agnès Aubouy2, Lucien Maciejewski3, Jacques Brocard3, Jacques Lébibi1 and Philippe Deloron2,4

1 Université des Sciences et Techniques de Masuku (USTM), Franceville; 2 Centre International de Recherches Médicales de Franceville (CIRMF), B.P. 769 Franceville, Gabon; 3 Université des Sciences et Techniques de Lille (USL), Villeneuve d’Ascq; 4 Institut de Recherche pour le Développement UR010, Faculté de Pharmacie, Université Paris 5, Paris, France

Received 9 July 2002; returned 26 September 2002; revised 6 October 2002; accepted 21 January 2003

Objectives: To assess the activity of a new organometallic chloroquine analogue, ferroquine, against numerous Plasmodium falciparum isolates from Gabon.

Methods: The in vitro susceptibility of 116 P. falciparum isolates to chloroquine and ferroquine was assessed using the isotopic microtest. All isolates were from outpatients in the Franceville and Bakoumba medical centres in the province of Haut-Ogooué, south-east Gabon.

Results: The in vitro resistance to chloroquine was 51.8% in Franceville and 96.7% in Bakoumba. The IC50 geometric mean (95% CI) of ferroquine against isolates in Franceville was 16.0 (14.4–17.8) nM, with individual values ranging from 1.0 to 47.0 nM; in Bakoumba it was 27.9 (23.4–33.2) nM, with individual values ranging from 1.0 to 62.0 nM. Compared with chloroquine, ferroquine was 5.3 times more active on isolates susceptible to chloroquine, and 13.3 times more active on isolates resistant to chloroquine. A weak positive correlation was observed between responses of these two drugs, but too low to demonstrate cross-resistance.

Conclusions: Ferroquine may be useful as an alternative drug for treating chloroquine-resistant malaria.

Keywords: chloroquine, ferrocene, malaria

* Corresponding author. Tel: +241-677092; Fax: +241-677295; E-mail: cnkoule{at}yahoo.fr


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