Skip Navigation


JAC Advance Access originally published online on January 28, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
51/3/707    most recent
dkg121v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Jones, H. E.
Right arrow Articles by Gill, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jones, H. E.
Right arrow Articles by Gill, M. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2003) 51, 707-710
© 2003 The British Society for Antimicrobial Chemotherapy

A multidrug efflux phenotype mutant of Streptococcus pyogenes

H. E. Jones, N. P. Brenwald, K. A. Owen and M. J. Gill*

Division of Immunity & Infection, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Received 20 September 2001; returned 8 February 2002; revised 24 October 2002; accepted 13 December 2002

We describe a mutant of Streptococcus pyogenes NCTC 8198 with a multidrug efflux phenotype. A mutant selected with ethidium bromide showed a four-fold rise in MIC of norfloxacin, a 16-fold rise in MIC of ethidium bromide and an eight-fold rise in MIC of acriflavine when compared with the parent strain. The MICs were unaffected by the efflux pump inhibitors reserpine, rescinnamine and verapamil. The mutant’s ethidium bromide MIC was reduced two-fold by norfloxacin. Ethidium bromide accumulation after 10 min was 58% lower in the mutant compared with the parent. This difference was not affected by carbonyl cyanide m-chlorophenylhydrazone.

* Corresponding author. Tel: +44-121-414-3634; Fax: +44-121-414-3454; E-mail: m.j.gill{at}bham.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Microbiol. Mol. Biol. Rev.Home page
J. Lubelski, W. N. Konings, and A. J. M. Driessen
Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria
Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 463 - 476.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
R. Alonso, E. Mateo, M. Galimand, J. Garaizar, P. Courvalin, and R. Cisterna
Clonal Spread of Pediatric Isolates of Ciprofloxacin-Resistant, emm Type 6 Streptococcus pyogenes
J. Clin. Microbiol., May 1, 2005; 43(5): 2492 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
S. Malhotra-Kumar, C. Lammens, S. Chapelle, C. Mallentjer, J. Weyler, and H. Goossens
Clonal spread of fluoroquinolone non-susceptible Streptococcus pyogenes
J. Antimicrob. Chemother., March 1, 2005; 55(3): 320 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
B. Malbruny, A. M. Werno, T. P. Anderson, D. R. Murdoch, and R. Leclercq
A new phenotype of resistance to lincosamide and streptogramin A-type antibiotics in Streptococcus agalactiae in New Zealand
J. Antimicrob. Chemother., December 1, 2004; 54(6): 1040 - 1044.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.