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JAC Advance Access originally published online on February 11, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 593-597
© 2003 The British Society for Antimicrobial Chemotherapy

The in vitro susceptibility of Scedosporium prolificans to ajoene, allitridium and a raw extract of garlic (Allium sativum)

Stephen R. Davis1,*, Rosemary Perrie1 and Rafael Apitz-Castro2

1 Mycology Unit, Women’s and Children’s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia; 2 Instituto Venezolano de Investigaciones Científicas (IVIC), Lab. Trombosis Experimental Centro de Biofísisca y Bioquímica, Caracas, Ap. 21827, 1020-A, Venezuela

Received 15 June 2002; returned 29 October 2002; revised 6 January 2003; accepted 10 January 2003

The in vitro susceptibility of 20 medical isolates of Scedosporium prolificans to ajoene, allitridium and raw garlic extract derived from cloves of garlic (Allium sativum) was tested using the NCCLS reference method (with minor modifications) for broth microdilution. The results demonstrate that both garlic derivatives and raw garlic extract appear to have in vitro activity against S. prolificans.

Keywords: antifungal, ajoene, allitridium, garlic

* Corresponding author. Tel: +61-8-81617365; Fax +61-8-81617589; E-mail: sdavis{at}esc.net.au


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