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JAC Advance Access originally published online on January 14, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 443-446
© 2003 The British Society for Antimicrobial Chemotherapy

Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials

Glenn A. Pankuch1, Michael R. Jacobs2 and Peter C. Appelbaum1,*

1 Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033; 2 Case Western Reserve University, Cleveland, OH 44106, USA

Received 13 September 2002; returned 7 November 2002; revised 7 November 2002; accepted 19 November 2002

A spectrum of pneumococci with varying susceptibilities to ß-lactams, macrolides and quinolones was tested for susceptibility to nine antibiotics, including the novel lipopeptide daptomycin. Daptomycin was active against all strains (MIC range <=0.5 mg/L; MIC50 0.125 mg/L; MIC90 0.25 mg/L). All pneumococci were susceptible to vancomycin, teicoplanin, linezolid and quinupristin/dalfopristin, with MICs < 4.0 mg/L. Time–kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h.

Keywords: pneumococci, daptomycin, MIC, time–kill

* Corresponding author. Tel: +1-717-531-5113; Fax: +1-717-531-7953; E-mail: pappelbaum{at}psu.edu


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