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JAC Advance Access originally published online on January 14, 2003
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Journal of Antimicrobial Chemotherapy (2003) 51, 347-352
© 2003 The British Society for Antimicrobial Chemotherapy

Multicentre surveillance of Pseudomonas aeruginosa susceptibility patterns in nosocomial infections

J. Van Eldere*

Rega Institute and Laboratory of Microbiology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium

Received 18 September 2002; returned 23 October 2002; revised 25 November 2002; accepted 26 November 2002

Objectives: To determine susceptibility rates and patterns in Pseudomonas aeruginosa strains isolated from nosocomial infections.

Methods: Seven hundred and sixteen P. aeruginosa isolates from 40 different hospitals in Belgium and the Grand Duchy of Luxembourg were collected in 1999.

Results: Resistance rates varied significantly between hospitals. Of the fluoroquinolones, ciprofloxacin showed least resistance (24%), levofloxacin showed 27.5% resistance and ofloxacin 37.5%. Of the aminoglycosides, amikacin was the most potent antibiotic (10.5% resistance), followed by isepamicin (12%), tobramycin (19.5%) and gentamicin (23.5%). Of the ß-lactam antibiotics, meropenem was the most active (9.5% resistance); piperacillin and piperacillin/tazobactam had, respectively, 24% and 17.5% resistance, ceftazidime 28.5%, cefepime 29.5%, ticarcillin/clavulanic acid 37% and aztreonam 55.5%. MIC distribution curves show the presence of significant subpopulations, with MICs just below breakpoint for many antibiotics.

Conclusion: Resistance of P. aeruginosa to penicillins, cephalosporins, fluoroquinolones and aminoglycosides varies between hospitals, but is increasing.

Keywords: Pseudomonas aeruginosa, nosocomial infections, susceptibility rates, surveillance

* Tel: +32-16-34-79-02; Fax: +32-16-34-79-31; E-mail: johan.vaneldere{at}uz.kuleuven.ac.be


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