Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Casal, J.
Right arrow Articles by Fenoll, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Casal, J.
Right arrow Articles by Fenoll, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2002) 50, 83-86
© 2002 The British Society for Antimicrobial Chemotherapy

Supplement

ß-Lactam activity against resistant pneumococcal strains is enhanced by the immune system

J. Casal1,*, M. J. Giménez2, L. Aguilar2, J. Yuste1, I. Jado1, D. Tarragó1 and A. Fenoll1

1 Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ctra Majadahonda-Pozuelo, km. 2, 28220 Majadahonda, Madrid; 2 Medical Department, GlaxoSmithKline, Tres Cantos, Madrid, Spain

Abstract

Pandemic resistance in Streptococcus pneumoniae is compromising antibiotic activity. Antibiotics that act on the cell wall, such as ß-lactams, may have a combined effect with the immune system against S. pneumoniae, since both act on the bacterial envelope. This combined effect can be studied in vitro or in vivo with respect to bacterial killing, since lysis is the end-point of both ß-lactams and the immune system. We review here the in vitro increase in the bactericidal activity of aminopenicillins by non-specific immunity (complement and polymorphonuclear leucocytes). Few data are available on the collaboration of specific immunity and ß-lactams. We also review the effect of the presence of specific antibodies on the in vivo T > MIC needed for the therapeutic efficacy of amoxicillin, and on blood bacterial clearance in animal models. The effect that immunity has on pharmacodynamic parameters, such as T > MIC, in non-human studies may be used as a tool to predict the effect of these pharmacodynamic variations in overcoming resistance and its selection, in the context of increasing the use of pneumococcal conjugated vaccines.

Footnotes

* Corresponding author. Tel.: +34-91-509-79-75; Fax.: +34-91-509-79-66; E-mail: jcasal{at}isciii.es


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
D. Sevillano, M. J. Gimenez, L. Alou, L. Aguilar, F. Cafini, M. Torrico, N. Gonzalez, O. Echeverria, P. Coronel, and J. Prieto
Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae
J. Antimicrob. Chemother., July 1, 2007; 60(1): 156 - 158.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
L. Alou, L. Aguilar, D. Sevillano, M.-J. Gimenez, B. Laguna, O. Echeverria, A. Carcas, R. Lubomirov, J. Casal, and J. Prieto
Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers
J. Antimicrob. Chemother., May 1, 2005; 55(5): 742 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
D. Tarrago, L. Aguilar, M. J. Gimenez, A. Fenoll, and J. Casal
Effects of Amoxicillin Subinhibitory Concentrations on the Cross-Protection Developed by Pneumococcal Antibodies in Mouse Sepsis Caused by an Amoxicillin-Resistant Serotype 6B Streptococcus pneumoniae Strain
Antimicrob. Agents Chemother., November 1, 2004; 48(11): 4144 - 4147.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.