Journal of Antimicrobial Chemotherapy (2002) 50, 1-6
© 2002 The British Society for Antimicrobial Chemotherapy
Supplement |
The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae
Department of International Health, Rollins School of Public Health and Division of Infectious Diseases, School of Medicine, Emory University, 1518 Clifton Road NE, Room 764, Atlanta, GA 30322, USA; MRC/NHLS/ Wits Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa
Abstract
A small number of pneumococcal clones dominate the population of antibiotic-resistant pneumococci. The emergence of fluoroquinolone resistance in these clones predicts the dissemination of fluoroquinolone resistance in countries where the clones are present and community use of fluoroquinolones for respiratory infections is common. The molecular basis of resistance to a number of classes of antimicrobials can be used to predict the likelihood of dissemination of the resistance genes.
Footnotes
* Tel: +1-404-712-9001; Fax: +1-404-727-4590; E-mail: kklugma{at}sph.emory.edu
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